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If the arrangement of the groups on the active site or the substrate was even slightly different, the bonding almost certainly wouldn't be as good - and in that sense, a different substrate wouldn't fit the active site on the enzyme.
Ribulose phosphate epimerase is an isomerase that catalyzes the interconversion of ribulose-5-phosphate and xylulose-5-phosphate. And, finally, hexokinaseis a ligase that catalyzes the interconversion of glucose and ATP with glucose-6-phosphate and ADP.
The mitochondrial DNA is restricted to the matrix that also contains a host of enzymes and ribosomes needed for protein synthesis. Several of the critical metabolic steps of cellular respiration are being catalyzed by the enzymes that can diffuse through the mitochondrial matrix. The enzyme that generates ATP and other proteins that are involved in respiration are embedded within the inner membrane of the mitochondrion. The cristae’s enfolding is can dramatically increase the surface area, which is available for the hosting of enzymes responsible for cellular respiration.
The excretion of KLK9 in urine has been associated to cardiac hypertrophy and aorta wall thickness in animal models